Evaluating the Limitations of Protein Sequence Representations for Parkinson's Disease Classification

arXiv:2604.11852v1 Announce Type: cross Abstract: The identification of reliable molecular biomarkers for Parkinson's disease remains challenging due to its multifactorial nature. Although protein sequences constitute a fundamental and widely available source of biological information, their standalone discriminative capacity for complex disease classification remains unclear. In this work, we present a controlled and leakage-free evaluation of multiple representations derived exclusively from p